5VD7
CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-098, a MK1775 analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Wee1-like protein kinase | polymer | 289 | 32440.9 | 1 | UniProt (P30291) Pfam (PF00069) In PDB | Homo sapiens (Human) | WEE1hu,Wee1A kinase |
| 2 | A | 6-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | non-polymer | 518.6 | 1 | Chemie (99V) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A: 291 - 575 (UniProt: P30291)
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | expression tag |
| Ala 288 | - | expression tag |
| Gly 289 | - | expression tag |
| Ser 290 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32440.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 616.1 | |
| All* | Total formula weight | 33057.0 |
