5V87

Crystal structure of LARP1-unique domain DM15 bound to m7GpppC

Summary for 5V87

• Entry DOI: 10.2210/pdb5v87/pdb
• Related: 5v7c
• Descriptor: La-related protein 1, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate, ... (4 entities in total)
• Functional Keywords: cap-binding, rna-binding, dm15, 5'top, rna binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q6PKG0
• Total number of polymer chains: 2
• Total formula weight: 40535.20

Authors

Berman, A.J.,Lahr, R.M. (deposition date: 2017-03-21, release date: 2017-04-19, Last modification date: 2023-10-04)

• Primary citation: Lahr, R.M.,Fonseca, B.D.,Ciotti, G.E.,Al-Ashtal, H.A.,Jia, J.J.,Niklaus, M.R.,Blagden, S.P.,Alain, T.,Berman, A.J.; La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.; Elife, 6:-, 2017; PubMed: 28379136; DOI: 10.7554/eLife.24146

Experimental method

X-RAY DIFFRACTION (1.692 Å)