5V87

Crystal structure of LARP1-unique domain DM15 bound to m7GpppC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	La-related protein 1	polymer	162	19616.3	2	UniProt (Q6PKG0) Pfam (PF21071) In PDB	Homo sapiens (Human)	La ribonucleoprotein domain family member 1
2	A	7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE	non-polymer		539.2	1	Chemie (MGT)
3	B	[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate	non-polymer		763.4	1	Chemie (91P)
4		water	water		18.0	224	Chemie (HOH)

Sequence modifications

A, B: 796 - 946 (UniProt: Q6PKG0)

PDB	External Database	Details
Gly 785	-	expression tag
His 786	-	expression tag
Ser 787	-	expression tag
Gly 788	-	expression tag
Gly 789	-	expression tag
Gly 790	-	expression tag
Gly 791	-	expression tag
Gly 792	-	expression tag
Gly 793	-	expression tag
His 794	-	expression tag
Met 795	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	39232.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1302.6
All*	Total formula weight	40535.2

*Water molecules are not included.