5V39

Crystal structure of human vitamin D receptor ligand binding domain in complex with a VDRM

Summary for 5V39

Entry DOI	10.2210/pdb5v39/pdb
Descriptor	Vitamin D3 receptor, 5-(3-{4-[(2S)-2-hydroxy-3,3-dimethylbutoxy]-3-methylphenyl}pentan-3-yl)-3-methyl-N-(1H-tetrazol-5-yl)thiophene-2-carboxamide (3 entities in total)
Functional Keywords	vdr, lbd, vdrm, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29645.33
Authors	Wang, Y.,Pelletier, L. (deposition date: 2017-03-06, release date: 2018-03-14, Last modification date: 2024-03-06)
Primary citation	Zheng, J.,Chang, M.R.,Stites, R.E.,Wang, Y.,Bruning, J.B.,Pascal, B.D.,Novick, S.J.,Garcia-Ordonez, R.D.,Stayrook, K.R.,Chalmers, M.J.,Dodge, J.A.,Griffin, P.R. HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions. Nat Commun, 8:923-923, 2017 Cited by PubMed: 29030554 DOI: 10.1038/s41467-017-00978-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation