5UL0
S. CEREVISIAE CYP51 COMPLEXED WITH VT-1161
Summary for 5UL0
Entry DOI | 10.2210/pdb5ul0/pdb |
Related | 4WMZ 5U1F |
Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, ... (5 entities in total) |
Functional Keywords | vt-1161, cyp51, oxidoreductase-oxidoreducatse inhibitor complex, sterol biosynthesis, oxidoreductase |
Biological source | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) |
Total number of polymer chains | 1 |
Total formula weight | 61969.90 |
Authors | Tyndall, J.D.,Keniya, M.V.,Sabherwal, M.,Monk, B.C. (deposition date: 2017-01-23, release date: 2017-02-15, Last modification date: 2023-10-04) |
Primary citation | Monk, B.C.,Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Graham, D.O.,Hassan, H.F.,Chen, D.,Tyndall, J.D.A. Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161. Antimicrob.Agents Chemother., 63:-, 2019 Cited by PubMed: 30397057DOI: 10.1128/AAC.02114-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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