4WMZ
S. cerevisiae CYP51 complexed with fluconazole in the active site
Summary for 4WMZ
| Entry DOI | 10.2210/pdb4wmz/pdb |
| Related | 4K0F 4LXJ |
| Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total) |
| Functional Keywords | fluconazole, cyp51, oxidoreductase-oxidoreducatse inhibitor complex, oxidoreductase/oxidoreducatse inhibitor |
| Biological source | Saccharomyces cerevisiae (Baker's yeast) |
| Total number of polymer chains | 1 |
| Total formula weight | 62807.97 |
| Authors | Sagatova, A.,Keniya, M.V.,Wilson, R.,Wilbanks, S.M.,Monk, B.C.,Tyndall, J.D.A. (deposition date: 2014-10-09, release date: 2015-07-01, Last modification date: 2023-09-27) |
| Primary citation | Sagatova, A.A.,Keniya, M.V.,Wilson, R.K.,Monk, B.C.,Tyndall, J.D. Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase. Antimicrob.Agents Chemother., 59:4982-4989, 2015 Cited by PubMed: 26055382DOI: 10.1128/AAC.00925-15 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
Download full validation report
