5UL0

S. CEREVISIAE CYP51 COMPLEXED WITH VT-1161

Summary for 5UL0

Entry DOI	10.2210/pdb5ul0/pdb
Related	4WMZ 5U1F
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, ... (5 entities in total)
Functional Keywords	vt-1161, cyp51, oxidoreductase-oxidoreducatse inhibitor complex, sterol biosynthesis, oxidoreductase
Biological source	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Total number of polymer chains	1
Total formula weight	61969.90
Authors	Tyndall, J.D.,Keniya, M.V.,Sabherwal, M.,Monk, B.C. (deposition date: 2017-01-23, release date: 2017-02-15, Last modification date: 2023-10-04)
Primary citation	Monk, B.C.,Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Graham, D.O.,Hassan, H.F.,Chen, D.,Tyndall, J.D.A. Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161. Antimicrob.Agents Chemother., 63:-, 2019 Cited by PubMed: 30397057 DOI: 10.1128/AAC.02114-18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation