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5UHN

Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation

Summary for 5UHN
Entry DOI10.2210/pdb5uhn/pdb
Related5UGL 5UGX 5UI0
DescriptorFibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
Functional Keywordstyrosine kinase domain gain-of-function atp analog cell surface receptor, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight75404.33
Authors
Mohammadi, M.,Chen, H. (deposition date: 2017-01-11, release date: 2017-02-22, Last modification date: 2023-10-04)
Primary citationChen, H.,Marsiglia, W.M.,Cho, M.K.,Huang, Z.,Deng, J.,Blais, S.P.,Gai, W.,Bhattacharya, S.,Neubert, T.A.,Traaseth, N.J.,Mohammadi, M.
Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6:-, 2017
Cited by
PubMed: 28166054
DOI: 10.7554/eLife.21137
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.909 Å)
Structure validation

217705

건을2024-03-27부터공개중

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