5UHN
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 801 |
| Chain | Residue |
| A | ARG625 |
| A | ARG649 |
| A | TYR656 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue ACP A 802 |
| Chain | Residue |
| A | ALA565 |
| A | ALA567 |
| A | ASN571 |
| A | ASP644 |
| A | MG803 |
| B | ALA491 |
| A | LEU487 |
| A | GLY488 |
| A | GLU489 |
| A | GLY490 |
| A | ALA515 |
| A | LYS517 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 803 |
| Chain | Residue |
| A | ARG630 |
| A | ASN631 |
| A | ASP644 |
| A | ACP802 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 801 |
| Chain | Residue |
| B | ARG625 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue ACP B 802 |
| Chain | Residue |
| B | LEU487 |
| B | GLU489 |
| B | GLY490 |
| B | ALA491 |
| B | PHE492 |
| B | GLY493 |
| B | ALA515 |
| B | VAL564 |
| B | ALA565 |
| B | TYR566 |
| B | ALA567 |
| B | ASN571 |
| B | ASN631 |
| B | LEU633 |
| B | ASP644 |
| B | MG803 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 803 |
| Chain | Residue |
| B | ARG630 |
| B | ASN631 |
| B | ASP644 |
| B | ACP802 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 31 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVmAeavgidkdkpkeavt...VAVK |
| Chain | Residue | Details |
| A | LEU487-LYS517 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV |
| Chain | Residue | Details |
| A | CYS622-VAL634 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"17803937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19410646","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
