5UCJ
Hsp90b N-terminal domain with inhibitors
Summary for 5UCJ
Entry DOI | 10.2210/pdb5ucj/pdb |
Related | 5UCH 5UCI |
Descriptor | Heat shock protein HSP 90-beta, (5-fluoroisoindolin-2-yl)(4-hydroxy-5-isopropylbenzo[d]isoxazol-7-yl)methanone, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | hsp90 inhibitor, chaperone-inhibitor complex, chaperone/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P08238 |
Total number of polymer chains | 4 |
Total formula weight | 100161.14 |
Authors | |
Primary citation | Khandelwal, A.,Kent, C.N.,Balch, M.,Peng, S.,Mishra, S.J.,Deng, J.,Day, V.W.,Liu, W.,Subramanian, C.,Cohen, M.,Holzbeierlein, J.M.,Matts, R.,Blagg, B.S.J. Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor. Nat Commun, 9:425-425, 2018 Cited by PubMed: 29382832DOI: 10.1038/s41467-017-02013-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.693 Å) |
Structure validation
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