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5UCI

Hsp90b N-terminal domain with inhibitors

Summary for 5UCI
Entry DOI10.2210/pdb5uci/pdb
Related5UCH 5UCJ
DescriptorHeat shock protein HSP 90-beta, (2,4-Dihydroxy-3-(hydroxymethyl)-5-isopropylphenyl)(isoindolin-2-yl)methanone, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywordshsp90 inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P08238
Total number of polymer chains4
Total formula weight100137.17
Authors
Peng, S.,Balch, M.,Matts, R.,Deng, J. (deposition date: 2016-12-22, release date: 2018-01-03, Last modification date: 2023-10-04)
Primary citationKhandelwal, A.,Kent, C.N.,Balch, M.,Peng, S.,Mishra, S.J.,Deng, J.,Day, V.W.,Liu, W.,Subramanian, C.,Cohen, M.,Holzbeierlein, J.M.,Matts, R.,Blagg, B.S.J.
Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor.
Nat Commun, 9:425-425, 2018
Cited by
PubMed: 29382832
DOI: 10.1038/s41467-017-02013-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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