5UCH

Hsp90b N-terminal domain with inhibitors

Summary for 5UCH

• Entry DOI: 10.2210/pdb5uch/pdb
• Related: 5UCI 5UCJ
• Descriptor: Heat shock protein HSP 90-beta, 2-(5-Hydroxy-4-(isoindoline-2-carbonyl)-2-isopropylphenyl)acetonitrile, GLYCEROL, ... (5 entities in total)
• Functional Keywords: hsp90, inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P08238
• Total number of polymer chains: 4
• Total formula weight: 100109.21

Authors

Peng, S.,Balch, M.,Matts, R.,Deng, J. (deposition date: 2016-12-22, release date: 2018-01-10, Last modification date: 2023-10-04)

• Primary citation: Khandelwal, A.,Kent, C.N.,Balch, M.,Peng, S.,Mishra, S.J.,Deng, J.,Day, V.W.,Liu, W.,Subramanian, C.,Cohen, M.,Holzbeierlein, J.M.,Matts, R.,Blagg, B.S.J.; Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor.; Nat Commun, 9:425-425, 2018; PubMed: 29382832; DOI: 10.1038/s41467-017-02013-1

Experimental method

X-RAY DIFFRACTION (2.654 Å)