Hsp90b N-terminal domain with inhibitors

Summary for 5UCJ

Related5UCH 5UCI
DescriptorHeat shock protein HSP 90-beta, (5-fluoroisoindolin-2-yl)(4-hydroxy-5-isopropylbenzo[d]isoxazol-7-yl)methanone, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywordshsp90 inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  P08238
Total number of polymer chains4
Total molecular weight100161.14
Peng, S.,Balch, M.,Matts, R.,Deng, J. (deposition date: 2016-12-22, release date: 2018-01-10, Last modification date: 2018-03-07)
Primary citation
Khandelwal, A.,Kent, C.N.,Balch, M.,Peng, S.,Mishra, S.J.,Deng, J.,Day, V.W.,Liu, W.,Subramanian, C.,Cohen, M.,Holzbeierlein, J.M.,Matts, R.,Blagg, B.S.J.
Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor.
Nat Commun, 9:425-425, 2018
PubMed: 29382832 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-017-02013-1
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.200700.1%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5ucj
no rotation
Molmil generated image of 5ucj
rotated about x axis by 90°
Molmil generated image of 5ucj
rotated about y axis by 90°