5U08
Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured soil metagenomic sample in complex with sisomicin
Summary for 5U08
Entry DOI | 10.2210/pdb5u08/pdb |
Related | 5F46 5F47 5F48 5F49 5HMN |
Descriptor | aminoglycoside acetyltransferase meta-AAC0020, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | gnat fold, gcn5-n-acetyltransferase fold, acetyltransferase, aminoglycoside, sisomicin, antibiotic resistance, metagenome, soil, coenzyme a, structural genomics, center for structural genomics of infectious diseases, csgid, transferase-antibiotic complex, transferase/antibiotic |
Biological source | uncultured bacterium |
Total number of polymer chains | 4 |
Total formula weight | 76039.15 |
Authors | Xu, Z.,Skarina, T.,Wawrzak, Z.,Stogios, P.J.,Yim, V.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2016-11-23, release date: 2017-02-08, Last modification date: 2023-10-04) |
Primary citation | Xu, Z.,Stogios, P.J.,Quaile, A.T.,Forsberg, K.J.,Patel, S.,Skarina, T.,Houliston, S.,Arrowsmith, C.,Dantas, G.,Savchenko, A. Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes. ACS Infect Dis, 3:653-665, 2017 Cited by PubMed: 28756664DOI: 10.1021/acsinfecdis.7b00068 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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