5U08

Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured soil metagenomic sample in complex with sisomicin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue SIS A 201

Chain	Residue
A	PHE35
A	HOH503
B	TYR81
B	GLU122
B	GLU147
B	HOH312
A	ASP91
A	ASP128
A	HIS151
A	TYR153
A	HOH310
A	HOH351
A	HOH411
A	HOH426

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 202

Chain	Residue
A	ASN39
A	HOH372
A	HOH419
C	HOH334
D	HOH366
D	HOH493

---

site_id	AC3
Number of Residues	6
Details	binding site for residue ACT A 203

Chain	Residue
A	GLN99
A	ARG100
A	GLY104
A	TYR133
A	HOH342
A	HOH397

---

site_id	AC4
Number of Residues	14
Details	binding site for residue SIS A 204

Chain	Residue
A	GLU121
A	GLU122
A	GLU147
A	HOH306
A	HOH333
A	HOH338
B	PHE35
B	ASP91
B	ASP128
B	TYR153
B	HOH330
D	GLU117
D	HOH327
D	HOH508

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CA A 205

Chain	Residue
A	ASP44
A	HOH471
B	GLU83
B	HOH469
D	PHE40
D	HOH355

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA A 206

Chain	Residue
A	PHE40
A	HOH361
C	GLU83
C	HOH324
C	HOH427
D	ASP44

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CA B 201

Chain	Residue
A	HOH468
B	GLU14
B	ASP20
B	HOH345
B	HOH394
B	HOH439

---

site_id	AC8
Number of Residues	5
Details	binding site for residue ACT B 202

Chain	Residue
B	ARG29
B	PHE40
B	SER41
B	ILE42
D	LYS142

---

site_id	AC9
Number of Residues	14
Details	binding site for residue SIS C 201

Chain	Residue
C	TYR81
C	GLU121
C	GLU122
C	GLU147
C	HOH307
C	HOH321
C	HOH364
C	HOH368
C	HOH428
C	HOH460
D	PHE35
D	ASP91
D	ASP128
D	HOH328

---

site_id	AD1
Number of Residues	6
Details	binding site for residue CA C 202

Chain	Residue
C	GLU14
C	ASP20
C	HOH397
C	HOH400
D	HOH365
D	HOH448

---

site_id	AD2
Number of Residues	7
Details	binding site for residue CA C 203

Chain	Residue
C	GLU18
C	ASN53
C	HOH391
C	HOH398
C	HOH409
C	HOH439
D	HOH389

---

site_id	AD3
Number of Residues	8
Details	binding site for residue ACT C 204

Chain	Residue
C	VAL94
C	GLN99
C	ARG100
C	GLY104
C	TYR133
C	HOH320
C	HOH432
C	HOH438

---

site_id	AD4
Number of Residues	13
Details	binding site for residue SIS D 201

Chain	Residue
C	TYR90
C	ASP91
C	ASP128
C	HOH412
D	GLU121
D	GLU122
D	GLU147
D	HOH304
D	HOH317
D	HOH323
D	HOH388
D	HOH440
C	PHE35

---

site_id	AD5
Number of Residues	7
Details	binding site for residue ACT D 202

Chain	Residue
D	VAL94
D	GLN99
D	ARG100
D	GLY104
D	HOH324
D	HOH339
D	HOH438

---

site_id	AD6
Number of Residues	6
Details	binding site for residue MG D 203

Chain	Residue
C	HOH328
C	HOH361
D	GLU14
D	ASP20
D	HOH329
D	HOH373

---

site_id	AD7
Number of Residues	7
Details	binding site for residue MG D 204

Chain	Residue
A	HOH394
A	HOH488
B	HOH310
B	HOH334
D	ASN39
D	HOH439
D	HOH538

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