5U08
Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured soil metagenomic sample in complex with sisomicin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0008080 | molecular_function | N-acetyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0008080 | molecular_function | N-acetyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0008080 | molecular_function | N-acetyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue SIS A 201 |
| Chain | Residue |
| A | PHE35 |
| A | HOH503 |
| B | TYR81 |
| B | GLU122 |
| B | GLU147 |
| B | HOH312 |
| A | ASP91 |
| A | ASP128 |
| A | HIS151 |
| A | TYR153 |
| A | HOH310 |
| A | HOH351 |
| A | HOH411 |
| A | HOH426 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | ASN39 |
| A | HOH372 |
| A | HOH419 |
| C | HOH334 |
| D | HOH366 |
| D | HOH493 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 203 |
| Chain | Residue |
| A | GLN99 |
| A | ARG100 |
| A | GLY104 |
| A | TYR133 |
| A | HOH342 |
| A | HOH397 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue SIS A 204 |
| Chain | Residue |
| A | GLU121 |
| A | GLU122 |
| A | GLU147 |
| A | HOH306 |
| A | HOH333 |
| A | HOH338 |
| B | PHE35 |
| B | ASP91 |
| B | ASP128 |
| B | TYR153 |
| B | HOH330 |
| D | GLU117 |
| D | HOH327 |
| D | HOH508 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 205 |
| Chain | Residue |
| A | ASP44 |
| A | HOH471 |
| B | GLU83 |
| B | HOH469 |
| D | PHE40 |
| D | HOH355 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 206 |
| Chain | Residue |
| A | PHE40 |
| A | HOH361 |
| C | GLU83 |
| C | HOH324 |
| C | HOH427 |
| D | ASP44 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 201 |
| Chain | Residue |
| A | HOH468 |
| B | GLU14 |
| B | ASP20 |
| B | HOH345 |
| B | HOH394 |
| B | HOH439 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 202 |
| Chain | Residue |
| B | ARG29 |
| B | PHE40 |
| B | SER41 |
| B | ILE42 |
| D | LYS142 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for residue SIS C 201 |
| Chain | Residue |
| C | TYR81 |
| C | GLU121 |
| C | GLU122 |
| C | GLU147 |
| C | HOH307 |
| C | HOH321 |
| C | HOH364 |
| C | HOH368 |
| C | HOH428 |
| C | HOH460 |
| D | PHE35 |
| D | ASP91 |
| D | ASP128 |
| D | HOH328 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 202 |
| Chain | Residue |
| C | GLU14 |
| C | ASP20 |
| C | HOH397 |
| C | HOH400 |
| D | HOH365 |
| D | HOH448 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 203 |
| Chain | Residue |
| C | GLU18 |
| C | ASN53 |
| C | HOH391 |
| C | HOH398 |
| C | HOH409 |
| C | HOH439 |
| D | HOH389 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue ACT C 204 |
| Chain | Residue |
| C | VAL94 |
| C | GLN99 |
| C | ARG100 |
| C | GLY104 |
| C | TYR133 |
| C | HOH320 |
| C | HOH432 |
| C | HOH438 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue SIS D 201 |
| Chain | Residue |
| C | TYR90 |
| C | ASP91 |
| C | ASP128 |
| C | HOH412 |
| D | GLU121 |
| D | GLU122 |
| D | GLU147 |
| D | HOH304 |
| D | HOH317 |
| D | HOH323 |
| D | HOH388 |
| D | HOH440 |
| C | PHE35 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue ACT D 202 |
| Chain | Residue |
| D | VAL94 |
| D | GLN99 |
| D | ARG100 |
| D | GLY104 |
| D | HOH324 |
| D | HOH339 |
| D | HOH438 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 203 |
| Chain | Residue |
| C | HOH328 |
| C | HOH361 |
| D | GLU14 |
| D | ASP20 |
| D | HOH329 |
| D | HOH373 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue MG D 204 |
| Chain | Residue |
| A | HOH394 |
| A | HOH488 |
| B | HOH310 |
| B | HOH334 |
| D | ASN39 |
| D | HOH439 |
| D | HOH538 |
