5O4E
Crystal structure of VEGF in complex with heterodimeric Fcab JanusCT6
Summary for 5O4E
Entry DOI | 10.2210/pdb5o4e/pdb |
Related | 5K64 5K65 |
Descriptor | Immunoglobulin gamma-1 heavy chain, CACODYLATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (12 entities in total) |
Functional Keywords | antibody engineering, immunoglobulin g1, fc fragment, fcab, heterodimeric fcab, ch3 domain, vegf, vascular endothelial growth factor, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 130697.28 |
Authors | Mlynek, G.,Lobner, E.,Kubinger, K.,Humm, A.,Obinger, C.,Djinovic-Carugo, K. (deposition date: 2017-05-29, release date: 2017-08-30, Last modification date: 2020-07-29) |
Primary citation | Lobner, E.,Humm, A.S.,Mlynek, G.,Kubinger, K.,Kitzmuller, M.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C. Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex. MAbs, 9:1088-1104, 2017 Cited by PubMed: 28816592DOI: 10.1080/19420862.2017.1364825 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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