5LY2

JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Macrocyclic PEPTIDE Inhibitor CP2_R6Kme3 (13-mer)

5LY2 の概要

• エントリーDOI: 10.2210/pdb5ly2/pdb
• 関連するPDBエントリー: 2OX0 2YBP 4AI9 4BIS 4V2V 5LY1
• 分子名称: Lysine-specific demethylase 4A, CP2_R6Kme3, NICKEL (II) ION, ... (8 entities in total)
• 機能のキーワード: jmjd2a, kdm4a, oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, double-stranded beta helix, dsbh, facial triad, demethylase, histone, jmjc domain, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 186740.28

構造登録者

Chowdhury, R.,Madden, S.K.,Hopkinson, R.,Schofield, C.J. (登録日: 2016-09-23, 公開日: 2017-04-12, 最終更新日: 2024-01-17)

• 主引用文献: Kawamura, A.,Munzel, M.,Kojima, T.,Yapp, C.,Bhushan, B.,Goto, Y.,Tumber, A.,Katoh, T.,King, O.N.,Passioura, T.,Walport, L.J.,Hatch, S.B.,Madden, S.,Muller, S.,Brennan, P.E.,Chowdhury, R.,Hopkinson, R.J.,Suga, H.,Schofield, C.J.; Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.; Nat Commun, 8:14773-14773, 2017; PubMed: 28382930; DOI: 10.1038/ncomms14773

実験手法

X-RAY DIFFRACTION (2.43 Å)