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5LY2

JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Macrocyclic PEPTIDE Inhibitor CP2_R6Kme3 (13-mer)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Lysine-specific demethylase 4Apolymer38144326.34UniProt (O75164)
Pfam (PF02375)
Pfam (PF02373)
Homo sapiens (Human)JmjC domain-containing histone demethylation protein 3A,Jumonji domain-containing protein 2A
2E, F, G, H
(E, F, G, H)
CP2_R6Kme3polymer141928.24synthetic construct
3AA, I, O, V
(D, A, B, C)
NICKEL (II) IONnon-polymer58.74Chemie (NI)
4BA, J, P, W
(D, A, B, C)
ZINC IONnon-polymer65.44Chemie (ZN)
5DA, K, R, Y
(D, A, B, C)
N-OXALYLGLYCINEnon-polymer147.14Chemie (OGA)
6L, M, S, T, U
(A, B)
GLYCEROLnon-polymer92.15Chemie (GOL)
7CA, N, Q, X, Z
(D, B, C)
CHLORIDE IONnon-polymer35.55Chemie (CL)
8EA, FA, GA, HA, IA...
(A, B, C, D, E...)
waterwater18.0503Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 359 (UniProt: O75164)
PDBExternal DatabaseDetails
Met -21-expression tag
His -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
Ser -14-expression tag
Ser -13-expression tag
Gly -12-expression tag
Val -11-expression tag
Asp -10-expression tag
Leu -9-expression tag
Gly -8-expression tag
Thr -7-expression tag
Glu -6-expression tag
Asn -5-expression tag
Leu -4-expression tag
Tyr -3-expression tag
Phe -2-expression tag
Gln -1-expression tag
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight185017.8
Non-Polymers*Number of molecules22
Total formula weight1722.5
All*Total formula weight186740.3
*Water molecules are not included.

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PDB entries from 2025-07-09

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