Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17

Summary for 5L5U

Related PRD IDPRD_000991
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (18 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, proteasome, mutant, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight734056.38
Groll, M.,Huber, E.M. (deposition date: 2016-05-28, release date: 2016-11-09, Last modification date: 2016-12-21)
Primary citation
Huber, E.M.,Heinemeyer, W.,de Bruin, G.,Overkleeft, H.S.,Groll, M.
A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i.
EMBO J., 35:2602-2613, 2016
PubMed: 27789522 (PDB entries with the same primary citation)
DOI: 10.15252/embj.201695222
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21420.2%3.1%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16