5KNP

Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid

Summary for 5KNP

• Entry DOI: 10.2210/pdb5knp/pdb
• Related: 5KNQ 5KNR 5KNS 5KNT 5KNU 5KNV 5KNX 5KNY
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, [(3~{S},4~{R})-4-(6-oxidanylidene-1~{H}-purin-9-yl)pyrrolidin-3-yl]oxymethylphosphonic acid, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, phosphoribosyltransferase, nucleoside phosphonates, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Cellular location: Cytoplasm : P9WHQ9
• Total number of polymer chains: 4
• Total formula weight: 94038.37

Authors

Eng, W.S.,Rejman, D.,Keough, D.T.,Guddat, L.W. (deposition date: 2016-06-28, release date: 2017-09-20, Last modification date: 2023-09-27)

• Primary citation: Eng, W.S.,Rejman, D.,Keough, D.T.,Guddat, L.W.; Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)