5KNU

Crystal structure of E. coli hypoxanthine phosphoribosyltransferase in complexed with 9-[N,N-(Bis-3-phosphonopropyl)aminomethyl]-9-deazahypoxanthine

Summary for 5KNU

Entry DOI	10.2210/pdb5knu/pdb
Related	5KNP 5KNQ 5KNR 5KNS 5KNT 5KNV 5KNX 5KNY
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, 3-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)methyl-(3-phosphonopropyl)amino]propylphosphonic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	acyclic nucleoside phosphonate, echprt, phosphoribosyltransferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	42391.20
Authors	Eng, W.S.,Keough, D.T.,Baszczynski, O.,Hockova, D.,Janeba, Z. (deposition date: 2016-06-28, release date: 2017-07-19, Last modification date: 2023-09-27)
Primary citation	Eng, W.S.,Hockova, D.,Spacek, P.,Baszczynski, O.,Janeba, Z.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase Chemistryselect, 1:6267-6276, 2016 Cited by DOI: 10.1002/slct.201601679 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.808 Å)

Structure validation