5KNP
Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 207 | 22969.8 | 4 | UniProt (P9WHQ9) Pfam (PF00156) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | HGPRTase |
| 2 | E, I, M, Q (A, B, C, D) | [(3~{S},4~{R})-4-(6-oxidanylidene-1~{H}-purin-9-yl)pyrrolidin-3-yl]oxymethylphosphonic acid | non-polymer | 315.2 | 4 | Chemie (6W7) | |||
| 3 | F, G, J, K, N... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 4 | H, L, P, T (A, B, C, D) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 4 | Chemie (POP) | |||
| 5 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 202 (UniProt: P9WHQ9)
| PDB | External Database | Details |
|---|---|---|
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 91879.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2159.2 | |
| All* | Total formula weight | 94038.4 |
