5KNP
Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0006177 | biological_process | GMP biosynthetic process |
A | 0006178 | biological_process | guanine salvage |
A | 0006188 | biological_process | IMP biosynthetic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0032263 | biological_process | GMP salvage |
A | 0032264 | biological_process | IMP salvage |
A | 0043101 | biological_process | purine-containing compound salvage |
A | 0046100 | biological_process | hypoxanthine metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0006177 | biological_process | GMP biosynthetic process |
B | 0006178 | biological_process | guanine salvage |
B | 0006188 | biological_process | IMP biosynthetic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0032263 | biological_process | GMP salvage |
B | 0032264 | biological_process | IMP salvage |
B | 0043101 | biological_process | purine-containing compound salvage |
B | 0046100 | biological_process | hypoxanthine metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
C | 0000166 | molecular_function | nucleotide binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006166 | biological_process | purine ribonucleoside salvage |
C | 0006177 | biological_process | GMP biosynthetic process |
C | 0006178 | biological_process | guanine salvage |
C | 0006188 | biological_process | IMP biosynthetic process |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0032263 | biological_process | GMP salvage |
C | 0032264 | biological_process | IMP salvage |
C | 0043101 | biological_process | purine-containing compound salvage |
C | 0046100 | biological_process | hypoxanthine metabolic process |
C | 0046872 | molecular_function | metal ion binding |
C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
D | 0000166 | molecular_function | nucleotide binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006166 | biological_process | purine ribonucleoside salvage |
D | 0006177 | biological_process | GMP biosynthetic process |
D | 0006178 | biological_process | guanine salvage |
D | 0006188 | biological_process | IMP biosynthetic process |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0032263 | biological_process | GMP salvage |
D | 0032264 | biological_process | IMP salvage |
D | 0043101 | biological_process | purine-containing compound salvage |
D | 0046100 | biological_process | hypoxanthine metabolic process |
D | 0046872 | molecular_function | metal ion binding |
D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue 6W7 A 301 |
Chain | Residue |
A | VAL124 |
A | POP304 |
A | HOH409 |
A | HOH419 |
A | HOH423 |
A | HOH429 |
A | VAL125 |
A | ASP126 |
A | SER127 |
A | GLY128 |
A | LYS154 |
A | PHE175 |
A | VAL176 |
A | ASP182 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 302 |
Chain | Residue |
A | ASP182 |
A | POP304 |
A | HOH406 |
A | HOH407 |
A | HOH419 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue MG A 303 |
Chain | Residue |
A | GLU122 |
A | ASP123 |
A | HOH402 |
A | HOH410 |
A | HOH428 |
A | HOH445 |
site_id | AC4 |
Number of Residues | 13 |
Details | binding site for residue POP A 304 |
Chain | Residue |
A | LEU65 |
A | LYS66 |
A | GLY67 |
A | ASP182 |
A | ARG188 |
A | 6W7301 |
A | MG302 |
A | HOH406 |
A | HOH410 |
A | HOH413 |
A | HOH419 |
A | HOH424 |
A | HOH428 |
site_id | AC5 |
Number of Residues | 12 |
Details | binding site for residue 6W7 B 301 |
Chain | Residue |
B | VAL124 |
B | VAL125 |
B | ASP126 |
B | SER127 |
B | GLY128 |
B | LYS154 |
B | PHE175 |
B | VAL176 |
B | POP304 |
B | HOH410 |
B | HOH412 |
B | HOH419 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue MG B 302 |
Chain | Residue |
B | ASP182 |
B | POP304 |
B | HOH409 |
B | HOH412 |
B | HOH424 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue MG B 303 |
Chain | Residue |
B | GLU122 |
B | ASP123 |
B | HOH401 |
B | HOH417 |
B | HOH427 |
site_id | AC8 |
Number of Residues | 13 |
Details | binding site for residue POP B 304 |
Chain | Residue |
B | LEU65 |
B | LYS66 |
B | GLY67 |
B | ASP182 |
B | ARG188 |
B | 6W7301 |
B | MG302 |
B | HOH404 |
B | HOH409 |
B | HOH412 |
B | HOH420 |
B | HOH427 |
B | HOH434 |
site_id | AC9 |
Number of Residues | 13 |
Details | binding site for residue 6W7 C 301 |
Chain | Residue |
C | VAL124 |
C | ASP126 |
C | SER127 |
C | GLY128 |
C | THR130 |
C | LYS154 |
C | PHE175 |
C | VAL176 |
C | ASP182 |
C | POP304 |
C | HOH403 |
C | HOH406 |
C | HOH428 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue MG C 302 |
Chain | Residue |
C | ASP182 |
C | POP304 |
C | HOH401 |
C | HOH414 |
C | HOH427 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue MG C 303 |
Chain | Residue |
C | GLU122 |
C | ASP123 |
C | HOH419 |
C | HOH429 |
C | HOH430 |
C | HOH438 |
site_id | AD3 |
Number of Residues | 11 |
Details | binding site for residue POP C 304 |
Chain | Residue |
C | GLY67 |
C | ASP182 |
C | ARG188 |
C | 6W7301 |
C | MG302 |
C | HOH401 |
C | HOH413 |
C | HOH427 |
C | HOH432 |
C | LEU65 |
C | LYS66 |
site_id | AD4 |
Number of Residues | 12 |
Details | binding site for residue 6W7 D 301 |
Chain | Residue |
D | VAL124 |
D | VAL125 |
D | ASP126 |
D | SER127 |
D | GLY128 |
D | LYS154 |
D | ASP174 |
D | PHE175 |
D | VAL176 |
D | POP304 |
D | HOH404 |
D | HOH430 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue MG D 302 |
Chain | Residue |
D | ASP182 |
D | POP304 |
D | HOH409 |
D | HOH411 |
D | HOH417 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue MG D 303 |
Chain | Residue |
D | GLU122 |
D | ASP123 |
D | HOH405 |
D | HOH418 |
D | HOH429 |
D | HOH431 |
site_id | AD7 |
Number of Residues | 11 |
Details | binding site for residue POP D 304 |
Chain | Residue |
D | LEU65 |
D | LYS66 |
D | GLY67 |
D | ASP182 |
D | ARG188 |
D | 6W7301 |
D | MG302 |
D | HOH403 |
D | HOH409 |
D | HOH417 |
D | HOH429 |
Functional Information from PROSITE/UniProt
site_id | PS00103 |
Number of Residues | 13 |
Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDVVDSGlT |
Chain | Residue | Details |
A | VAL118-THR130 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P0A9M2 |
Chain | Residue | Details |
A | ASP126 | |
B | ASP126 | |
C | ASP126 | |
D | ASP126 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25915781, ECO:0007744|PDB:4RHT, ECO:0007744|PDB:5KNP |
Chain | Residue | Details |
A | LYS66 | |
D | LYS66 | |
D | GLY67 | |
D | ARG188 | |
A | GLY67 | |
A | ARG188 | |
B | LYS66 | |
B | GLY67 | |
B | ARG188 | |
C | LYS66 | |
C | GLY67 | |
C | ARG188 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25915781, ECO:0007744|PDB:4RHT |
Chain | Residue | Details |
A | GLU122 | |
B | ASP182 | |
C | GLU122 | |
C | ASP123 | |
C | LYS154 | |
C | PHE175 | |
C | ASP182 | |
D | GLU122 | |
D | ASP123 | |
D | LYS154 | |
D | PHE175 | |
A | ASP123 | |
D | ASP182 | |
A | LYS154 | |
A | PHE175 | |
A | ASP182 | |
B | GLU122 | |
B | ASP123 | |
B | LYS154 | |
B | PHE175 |