5KNP
Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006178 | biological_process | guanine salvage |
| A | 0006188 | biological_process | IMP biosynthetic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0043101 | biological_process | purine-containing compound salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006178 | biological_process | guanine salvage |
| B | 0006188 | biological_process | IMP biosynthetic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0043101 | biological_process | purine-containing compound salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006178 | biological_process | guanine salvage |
| C | 0006188 | biological_process | IMP biosynthetic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0043101 | biological_process | purine-containing compound salvage |
| C | 0046100 | biological_process | hypoxanthine metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006178 | biological_process | guanine salvage |
| D | 0006188 | biological_process | IMP biosynthetic process |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0043101 | biological_process | purine-containing compound salvage |
| D | 0046100 | biological_process | hypoxanthine metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 6W7 A 301 |
| Chain | Residue |
| A | VAL124 |
| A | POP304 |
| A | HOH409 |
| A | HOH419 |
| A | HOH423 |
| A | HOH429 |
| A | VAL125 |
| A | ASP126 |
| A | SER127 |
| A | GLY128 |
| A | LYS154 |
| A | PHE175 |
| A | VAL176 |
| A | ASP182 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | ASP182 |
| A | POP304 |
| A | HOH406 |
| A | HOH407 |
| A | HOH419 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 303 |
| Chain | Residue |
| A | GLU122 |
| A | ASP123 |
| A | HOH402 |
| A | HOH410 |
| A | HOH428 |
| A | HOH445 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue POP A 304 |
| Chain | Residue |
| A | LEU65 |
| A | LYS66 |
| A | GLY67 |
| A | ASP182 |
| A | ARG188 |
| A | 6W7301 |
| A | MG302 |
| A | HOH406 |
| A | HOH410 |
| A | HOH413 |
| A | HOH419 |
| A | HOH424 |
| A | HOH428 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue 6W7 B 301 |
| Chain | Residue |
| B | VAL124 |
| B | VAL125 |
| B | ASP126 |
| B | SER127 |
| B | GLY128 |
| B | LYS154 |
| B | PHE175 |
| B | VAL176 |
| B | POP304 |
| B | HOH410 |
| B | HOH412 |
| B | HOH419 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 302 |
| Chain | Residue |
| B | ASP182 |
| B | POP304 |
| B | HOH409 |
| B | HOH412 |
| B | HOH424 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 303 |
| Chain | Residue |
| B | GLU122 |
| B | ASP123 |
| B | HOH401 |
| B | HOH417 |
| B | HOH427 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | binding site for residue POP B 304 |
| Chain | Residue |
| B | LEU65 |
| B | LYS66 |
| B | GLY67 |
| B | ASP182 |
| B | ARG188 |
| B | 6W7301 |
| B | MG302 |
| B | HOH404 |
| B | HOH409 |
| B | HOH412 |
| B | HOH420 |
| B | HOH427 |
| B | HOH434 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue 6W7 C 301 |
| Chain | Residue |
| C | VAL124 |
| C | ASP126 |
| C | SER127 |
| C | GLY128 |
| C | THR130 |
| C | LYS154 |
| C | PHE175 |
| C | VAL176 |
| C | ASP182 |
| C | POP304 |
| C | HOH403 |
| C | HOH406 |
| C | HOH428 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 302 |
| Chain | Residue |
| C | ASP182 |
| C | POP304 |
| C | HOH401 |
| C | HOH414 |
| C | HOH427 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 303 |
| Chain | Residue |
| C | GLU122 |
| C | ASP123 |
| C | HOH419 |
| C | HOH429 |
| C | HOH430 |
| C | HOH438 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue POP C 304 |
| Chain | Residue |
| C | GLY67 |
| C | ASP182 |
| C | ARG188 |
| C | 6W7301 |
| C | MG302 |
| C | HOH401 |
| C | HOH413 |
| C | HOH427 |
| C | HOH432 |
| C | LEU65 |
| C | LYS66 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for residue 6W7 D 301 |
| Chain | Residue |
| D | VAL124 |
| D | VAL125 |
| D | ASP126 |
| D | SER127 |
| D | GLY128 |
| D | LYS154 |
| D | ASP174 |
| D | PHE175 |
| D | VAL176 |
| D | POP304 |
| D | HOH404 |
| D | HOH430 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 302 |
| Chain | Residue |
| D | ASP182 |
| D | POP304 |
| D | HOH409 |
| D | HOH411 |
| D | HOH417 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 303 |
| Chain | Residue |
| D | GLU122 |
| D | ASP123 |
| D | HOH405 |
| D | HOH418 |
| D | HOH429 |
| D | HOH431 |
| site_id | AD7 |
| Number of Residues | 11 |
| Details | binding site for residue POP D 304 |
| Chain | Residue |
| D | LEU65 |
| D | LYS66 |
| D | GLY67 |
| D | ASP182 |
| D | ARG188 |
| D | 6W7301 |
| D | MG302 |
| D | HOH403 |
| D | HOH409 |
| D | HOH417 |
| D | HOH429 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDVVDSGlT |
| Chain | Residue | Details |
| A | VAL118-THR130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P0A9M2 |
| Chain | Residue | Details |
| A | ASP126 | |
| C | ASP126 | |
| D | ASP126 | |
| B | ASP126 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25915781, ECO:0007744|PDB:4RHT, ECO:0007744|PDB:5KNP |
| Chain | Residue | Details |
| B | GLY67 | |
| B | ARG188 | |
| C | LYS66 | |
| C | GLY67 | |
| C | ARG188 | |
| D | LYS66 | |
| D | GLY67 | |
| D | ARG188 | |
| A | LYS66 | |
| A | GLY67 | |
| A | ARG188 | |
| B | LYS66 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25915781, ECO:0007744|PDB:4RHT |
| Chain | Residue | Details |
| A | ASP182 | |
| B | GLU122 | |
| B | ASP123 | |
| B | LYS154 | |
| B | PHE175 | |
| B | ASP182 | |
| C | GLU122 | |
| C | ASP123 | |
| C | LYS154 | |
| C | PHE175 | |
| C | ASP182 | |
| D | GLU122 | |
| D | ASP123 | |
| D | LYS154 | |
| D | PHE175 | |
| D | ASP182 | |
| A | GLU122 | |
| A | ASP123 | |
| A | LYS154 | |
| A | PHE175 |
