5KGN

1.95A resolution structure of independent phosphoglycerate mutase from C. elegans in complex with a macrocyclic peptide inhibitor (2d)

Summary for 5KGN

Entry DOI	10.2210/pdb5kgn/pdb
Related	5KGL 5KGM
Descriptor	2,3-bisphosphoglycerate-independent phosphoglycerate mutase, macrocyclic peptide inhibitor, CHLORIDE ION, ... (8 entities in total)
Functional Keywords	metal binding, coupled enzyme assay, hts, structure activity relationship, rapid systems, high throughput enzymology, isomerase
Biological source	Caenorhabditis elegans More
Total number of polymer chains	4
Total formula weight	120870.56
Authors	Lovell, S.,Mehzabeen, N.,Battaile, K.P.,Yu, H.,Dranchak, P.,MacArthur, R.,Li, Z.,Carlow, T.,Suga, H.,Inglese, J. (deposition date: 2016-06-13, release date: 2017-04-05, Last modification date: 2023-09-27)
Primary citation	Yu, H.,Dranchak, P.,Li, Z.,MacArthur, R.,Munson, M.S.,Mehzabeen, N.,Baird, N.J.,Battalie, K.P.,Ross, D.,Lovell, S.,Carlow, C.K.,Suga, H.,Inglese, J. Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases. Nat Commun, 8:14932-14932, 2017 Cited by PubMed: 28368002 DOI: 10.1038/ncomms14932 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation