5JSJ

Crystal structure of Spindlin1 bound to compound EML631

Summary for 5JSJ

• Entry DOI: 10.2210/pdb5jsj/pdb
• Related: 5JSG
• Descriptor: Spindlin-1, [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: tudor domain, cell cycle
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9Y657
• Total number of polymer chains: 2
• Total formula weight: 52484.61

Authors

Su, X.,Li, H. (deposition date: 2016-05-08, release date: 2017-05-24, Last modification date: 2024-03-20)

• Primary citation: Bae, N.,Viviano, M.,Su, X.,Lv, J.,Cheng, D.,Sagum, C.,Castellano, S.,Bai, X.,Johnson, C.,Khalil, M.I.,Shen, J.,Chen, K.,Li, H.,Sbardella, G.,Bedford, M.T.; Developing Spindlin1 small-molecule inhibitors by using protein microarrays; Nat. Chem. Biol., 13:750-756, 2017; PubMed: 28504676; DOI: 10.1038/nchembio.2377

Experimental method

X-RAY DIFFRACTION (2.348 Å)