5JSJ
Crystal structure of Spindlin1 bound to compound EML631
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Spindlin-1 | polymer | 222 | 25509.7 | 2 | UniProt (Q9Y657) Pfam (PF02513) | Homo sapiens (Human) | Ovarian cancer-related protein,Spindlin1 |
| 2 | C, F (A, B) | [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone | non-polymer | 685.0 | 2 | Chemie (6PD) | |||
| 3 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | E, G (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A, B: 50 - 262 (UniProt: Q9Y657)
| PDB | External Database | Details |
|---|---|---|
| Met 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| His 45 | - | expression tag |
| His 46 | - | expression tag |
| His 47 | - | expression tag |
| Gly 48 | - | expression tag |
| Ser 49 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51019.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1465.1 | |
| All* | Total formula weight | 52484.6 |
