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5I2R

human PDE10A in complex with 3-(2-phenylpyrazol-3-yl)-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one

Summary for 5I2R
Entry DOI10.2210/pdb5i2r/pdb
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsphosphodiesterase, pde10, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q9Y233
Total number of polymer chains4
Total formula weight149049.86
Authors
Joseph, C.,Koerner, M.,Rudolph, M.G. (deposition date: 2016-02-09, release date: 2016-03-09)
Primary citationKuhn, B.,Guba, W.,Hert, J.,Banner, D.,Bissantz, C.,Ceccarelli, S.,Haap, W.,Korner, M.,Kuglstatter, A.,Lerner, C.,Mattei, P.,Neidhart, W.,Pinard, E.,Rudolph, M.G.,Schulz-Gasch, T.,Woltering, T.,Stahl, M.
A Real-World Perspective on Molecular Design.
J.Med.Chem., 59:4087-4102, 2016
Cited by
PubMed: 26878596
DOI: 10.1021/acs.jmedchem.5b01875
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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