5I2R
human PDE10A in complex with 3-(2-phenylpyrazol-3-yl)-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS529 |
| A | HIS563 |
| A | ASP564 |
| A | ASP674 |
| A | HOH919 |
| A | HOH975 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 802 |
| Chain | Residue |
| A | HOH975 |
| A | HOH990 |
| A | HOH992 |
| A | ASP564 |
| A | HOH908 |
| A | HOH938 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue 67A A 803 |
| Chain | Residue |
| A | TYR524 |
| A | PHE639 |
| A | LEU675 |
| A | ILE692 |
| A | TYR693 |
| A | MET713 |
| A | GLN726 |
| A | PHE729 |
| A | HOH916 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | HIS529 |
| B | HIS563 |
| B | ASP564 |
| B | ASP674 |
| B | HOH967 |
| B | HOH975 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 802 |
| Chain | Residue |
| B | ASP564 |
| B | HOH928 |
| B | HOH957 |
| B | HOH972 |
| B | HOH975 |
| B | HOH994 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue 67A B 803 |
| Chain | Residue |
| B | TYR524 |
| B | LEU635 |
| B | LEU675 |
| B | MET713 |
| B | GLN726 |
| B | PHE729 |
| B | HOH952 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ZN C 801 |
| Chain | Residue |
| C | HIS529 |
| C | HIS563 |
| C | ASP564 |
| C | ASP674 |
| C | HOH942 |
| C | HOH974 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 802 |
| Chain | Residue |
| C | ASP564 |
| C | HOH928 |
| C | HOH944 |
| C | HOH974 |
| C | HOH985 |
| C | HOH1011 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue 67A C 803 |
| Chain | Residue |
| C | LEU635 |
| C | LEU675 |
| C | SER677 |
| C | MET713 |
| C | GLN726 |
| C | PHE729 |
| C | HOH943 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN D 801 |
| Chain | Residue |
| D | HIS529 |
| D | HIS563 |
| D | ASP564 |
| D | ASP674 |
| D | MG802 |
| D | HOH909 |
| D | HOH919 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue MG D 802 |
| Chain | Residue |
| D | ASP564 |
| D | ZN801 |
| D | HOH903 |
| D | HOH909 |
| D | HOH917 |
| D | HOH920 |
| D | HOH925 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue 67A D 803 |
| Chain | Residue |
| D | TYR524 |
| D | HIS525 |
| D | LEU635 |
| D | LEU675 |
| D | SER677 |
| D | PHE696 |
| D | MET713 |
| D | GLN726 |
| D | PHE729 |
| D | HOH930 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS563-TYR574 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF |
| Chain | Residue | Details |
| A | CYS562 | |
| C | GLU606 | |
| C | GLY640 | |
| C | GLN659 | |
| D | CYS562 | |
| D | GLU606 | |
| D | GLY640 | |
| D | GLN659 | |
| A | GLU606 | |
| A | GLY640 | |
| A | GLN659 | |
| B | CYS562 | |
| B | GLU606 | |
| B | GLY640 | |
| B | GLN659 | |
| C | CYS562 |
