5I2R
CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C2(=NN(c1cccc(c1)OC(F)(F)F)C=CC2=O)c3ccnn3c4ccccc4, micromolar IC50=0.019462
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 318 | 36774.4 | 4 | UniProt (Q9Y233) | Homo sapiens (Human) | |
| 2 | E, H, K, N (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, L, O (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G, J, M, P (A, B, C, D) | 3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethoxy)phenyl]pyridazin-4(1H)-one | non-polymer | 398.3 | 4 | Chemie (67A) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 517 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 457 - 773 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Ala 456 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 147097.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1952.2 | |
| All* | Total formula weight | 149049.9 |
