5GJF
Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 3
Summary for 5GJF
Entry DOI | 10.2210/pdb5gjf/pdb |
Related | 5GJD 5GJG |
Descriptor | TAK1 kinase - TAB1 chimera fusion protein, N-(2-isopropoxy-4-(4-methylpiperazine-1-carbonyl)phenyl)-2-(3-(3-phenylureido)phenyl)thiazole-4-carboxamide (3 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, tak1-tab1 kinase, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 36129.67 |
Authors | Irie, M.,Nakamura, M.,Fukami, T.A.,Matsuura, T.,Morishima, K. (deposition date: 2016-06-29, release date: 2016-11-16, Last modification date: 2023-11-08) |
Primary citation | Muraoka, T.,Ide, M.,Irie, M.,Morikami, K.,Miura, T.,Nishihara, M.,Kashiwagi, H. Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD) Chem.Pharm.Bull., 64:1622-1629, 2016 Cited by PubMed: 27803473DOI: 10.1248/cpb.c16-00606 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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