5GJD
Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 2
Summary for 5GJD
| Entry DOI | 10.2210/pdb5gjd/pdb |
| Related | 5GJF 5GJG |
| Descriptor | TAK1 kinase - TAB1 chimera fusion protein, 1-(4-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-3-(5-(4-methylpiperazin-1-yl)naphthalen-2-yl)urea (3 entities in total) |
| Functional Keywords | transferase-transferase inhibitor complex, tak1-tab1 kinase, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 36023.53 |
| Authors | Irie, M.,Nakamura, M.,Fukami, T.A.,Matsuura, T.,Morishima, K. (deposition date: 2016-06-29, release date: 2016-11-16, Last modification date: 2023-11-08) |
| Primary citation | Muraoka, T.,Ide, M.,Irie, M.,Morikami, K.,Miura, T.,Nishihara, M.,Kashiwagi, H. Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD) Chem.Pharm.Bull., 64:1622-1629, 2016 Cited by PubMed: 27803473DOI: 10.1248/cpb.c16-00606 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
Download full validation report
