5GJG

Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 4

Summary for 5GJG

• Entry DOI: 10.2210/pdb5gjg/pdb
• Related: 5GJD 5GJF
• Descriptor: TAK1 kinase - TAB1 chimera fusion protein, N-(2-isopropoxy-4-(4-methylpiperazine-1-carbonyl)phenyl)-2-(3-(phenylcarbamoyl)phenyl)thiazole-4-carboxamide (3 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, tak1-tab1 kinase, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 36114.65

Authors

Irie, M.,Nakamura, M.,Fukami, T.A.,Matsuura, T.,Morishima, K. (deposition date: 2016-06-29, release date: 2016-11-16, Last modification date: 2023-11-08)

• Primary citation: Muraoka, T.,Ide, M.,Irie, M.,Morikami, K.,Miura, T.,Nishihara, M.,Kashiwagi, H.; Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD); Chem.Pharm.Bull., 64:1622-1629, 2016; PubMed: 27803473; DOI: 10.1248/cpb.c16-00606

Experimental method

X-RAY DIFFRACTION (2.61 Å)