5FZA
Crystal structure of the catalytic domain of human JARID1B in complex with 3D fragment 2-piperidin-4-yloxy-5-(trifluoromethyl)pyridine (N10072a) (ligand modelled based on PANDDA event map)
Summary for 5FZA
Entry DOI | 10.2210/pdb5fza/pdb |
Related | 5FYB 5FYC 5FYH 5FYI 5FYM 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5FZO |
Descriptor | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | oxidoreductase, jarid1b, plu1, pandda, fragment screening, structural genomics consortium, sgc |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : Q9UGL1 |
Total number of polymer chains | 1 |
Total formula weight | 56614.95 |
Authors | Nowak, R.,Krojer, T.,Pearce, N.,Johansson, C.,Gileadi, C.,Kupinska, K.,Strain-Damerell, C.,Szykowska, A.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,von Delft, F.,Brennan, P.E.,Oppermann, U. (deposition date: 2016-03-12, release date: 2016-03-30, Last modification date: 2024-01-10) |
Primary citation | Nowak, R.,Krojer, T.,Pearce, N.,Johansson, C.,Gileadi, C.,Kupinska, K.,Strain-Damerell, C.,Szykowska, A.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,von Delft, F.,Brennan, P.E.,Oppermann, U. Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with 3D Fragment 2-Piperidin-4-Yloxy-5-(Trifluoromethyl)Pyridine (N10072A) (Ligand Modelled Based on Pandda Event Map) To be Published, |
Experimental method | X-RAY DIFFRACTION (2.099 Å) |
Structure validation
Download full validation report