5FZH

Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment 4,5-dihydronaphtho(1,2-b)thiophene-2- carboxylicacid (N11181a) (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)

Summary for 5FZH

• Entry DOI: 10.2210/pdb5fzh/pdb
• Related: 5FYC 5FYH 5FYI 5FYM 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZI 5FZK 5FZL 5FZM 5FZO
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ... (9 entities in total)
• Functional Keywords: oxidoreductase, jarid1b, plu1, fragment screening, structural genomics consortium, sgc, diamond i04-1, pandda
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : Q9UGL1
• Total number of polymer chains: 1
• Total formula weight: 56623.49

Authors

Nowak, R.,Krojer, T.,Johansson, C.,Kupinska, K.,Szykowska, A.,Pearce, N.,Talon, R.,Collins, P.,Gileadi, C.,Strain-Damerell, C.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,von Delft, F.,Brennan, P.E.,Oppermann, U. (deposition date: 2016-03-14, release date: 2016-05-25, Last modification date: 2024-01-10)

• Primary citation: Nowak, R.,Krojer, T.,Johansson, C.,Kupinska, K.,Szykowska, A.,Pearce, N.,Talon, R.,Collins, P.,Gileadi, C.,Strain-Damerell, C.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,von Delft, F.,Brennan, P.E.,Oppermann, U.; Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Maybridge Fragment 4,5-Dihydronaphtho(1,2-B)Thiophene-2-Carboxylicacid (N11181A) (Ligand Modelled Based on Pandda Event Map, Sgc - Diamond I04-1 Fragment Screening); To be Published,

Experimental method

X-RAY DIFFRACTION (2.09 Å)