5FYY

Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment 3-pyridin-3-ylaniline (N05798a) (ligand modelled based on PANDDA event map)

Summary for 5FYY

• Entry DOI: 10.2210/pdb5fyy/pdb
• Related: 5FXV 5FXW 5FXX 5FXZ 5FY0 5FY1 5FY4 5FY5 5FY7 5FY8 5FY9 5FYB 5FYC 5FYH 5FYI 5FYM 5FYS 5FYT 5FYU 5FYV 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, CHLORIDE ION, ... (9 entities in total)
• Functional Keywords: oxidoreductase, jarid1b, plu1, pandda, fragment soaking, x-ray fragment screening
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : Q9UGL1
• Total number of polymer chains: 1
• Total formula weight: 57102.43

Authors

Nowak, R.,Krojer, T.,Johansson, C.,Gileadi, C.,Kupinska, K.,Strain-Damerell, C.,Szykowska, A.,Pearce, N.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,von Delft, F.,Brennan, P.E.,Oppermann, U. (deposition date: 2016-03-10, release date: 2016-03-23, Last modification date: 2024-01-10)

• Primary citation: Nowak, R.,Krojer, T.,Johansson, C.,Gileadi, C.,Kupinska, K.,Strain-Damerell, C.,Szykowska, A.,von Delft, F.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Oppermann, U.; Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with N05798A; To be Published,

Experimental method

X-RAY DIFFRACTION (2.18 Å)