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5FZ9

Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment thieno(3,2-b)thiophene-5-carboxylic acid (N06263b) (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)

Summary for 5FZ9
Entry DOI10.2210/pdb5fz9/pdb
Related5FYB 5FYC 5FYH 5FYI 5FYM 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5FZO
DescriptorLYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ... (10 entities in total)
Functional Keywordsoxidoreductase, jarid1b, plu1, fragment screening, structural genomics consortium, sgc, diamond i04-1, pandda
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus : Q9UGL1
Total number of polymer chains1
Total formula weight56866.23
Authors
Primary citationNowak, R.,Krojer, T.,Johansson, C.,Kupinska, K.,Szykowska, A.,Pearce, N.,Talon, R.,Collins, P.,Gileadi, C.,Strain-Damerell, C.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,von Delft, F.,Brennan, P.E.,Oppermann, U.
Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Maybridge Fragment Thieno(3,2-B)Thiophene -5-Carboxylic Acid (N06263B) (Ligand Modelled Based on Pandda Event Map, Sgc - Diamond I04-1 Fragment Screening)
To be Published,
Experimental method
X-RAY DIFFRACTION (2.06 Å)
Structure validation

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PDB entries from 2024-03-27

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