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5FYZ

Crystal structure of the catalytic domain of human JARID1B in complex with 3D fragment 2-(2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile (N10063a)

Summary for 5FYZ
Entry DOI10.2210/pdb5fyz/pdb
Related5FXV 5FXW 5FXX 5FXZ 5FY0 5FY1 5FY4 5FY5 5FY7 5FY8 5FY9 5FYB 5FYC 5FYH 5FYI 5FYM 5FYS 5FYT 5FYU 5FYV 5FYY 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD
DescriptorLYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, [(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]acetonitrile, ... (9 entities in total)
Functional Keywordsoxidoreductase, jarid1b, plu1, pandda, fragment soaking, x-ray fragment screening, structural genomics consortium, sgc
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus : Q9UGL1
Total number of polymer chains1
Total formula weight56669.41
Authors
Primary citationNowak, R.,Krojer, T.,Johansson, C.,Gileadi, C.,Kupinska, K.,Strain-Damerell, C.,Szykowska, A.,von Delft, F.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Oppermann, U.
Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with N10063A
To be Published,
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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