5FUY

catalytic domain of Thymidine kinase from Trypanosoma brucei with dTMP

Summary for 5FUY

• Entry DOI: 10.2210/pdb5fuy/pdb
• Related: 5FUV 5FUW 5FUX
• Descriptor: THYMDINE KINASE, PHOSPHATE ION, [(2R,3S,5R)-3-HYDROXY-5-[(5S)-5-METHYL-2,4-DIOXO-1,3-DIAZINAN-1-YL]OXOLAN-2-YL]METHYL DIHYDROGEN PHOSPHATE, ... (5 entities in total)
• Functional Keywords: transferase, thymidine kinase, t.brucei, tbtk, tkii, dtmp
• Biological source: TRYPANOSOMA BRUCEI
• Total number of polymer chains: 6
• Total formula weight: 126354.35

Authors

Timm, J.,Valente, M.,Castillo-Acosta, V.,Balzarini, T.,Nettleship, J.E.,Rada, H.,Wilson, K.S.,Gonzalez-Pacanowska, D. (deposition date: 2016-01-31, release date: 2016-07-27, Last modification date: 2024-01-10)

• Primary citation: Valente, M.,Timm, J.,Castillo-Acosta, V.M.,Ruiz-Perez, L.M.,Balzarini, T.,Nettleship, J.E.,Bird, L.E.,Rada, H.,Wilson, K.S.,Gonzalez-Pacanowska, D.; Cell Cycle Regulation and Novel Structural Features of Thymidine Kinase, an Essential Enzyme in Trypanosoma Brucei.; Mol.Microbiol., 102:365-, 2016; PubMed: 27426054; DOI: 10.1111/MMI.13467

Experimental method

X-RAY DIFFRACTION (2.8 Å)