5FPB

Crystal structure of human KDM4D in complex with 2-1H-pyrazol-4-yloxy- 3H,4H-pyrido-3,4-d-pyrimidin-4-one

5FPB の概要

• エントリーDOI: 10.2210/pdb5fpb/pdb
• 関連するPDBエントリー: 5FP3 5FP4 5FP7 5FP8 5FP9 5FPA
• 分子名称: LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, COBALT (II) ION, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, inhibitor, lysine specific histone demethylase, jmjd2d, kdm4d, jumonji
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q6B0I6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39560.61

構造登録者

Chung, C. (登録日: 2015-11-27, 公開日: 2016-01-27, 最終更新日: 2016-03-09)

• 主引用文献: Westaway, S.M.,Preston, A.G.S.,Barker, M.D.,Brown, F.,Brown, J.A.,Campbell, M.,Chung, C.,Diallo, H.,Douault, C.,Drewes, G.,Eagle, R.,Gordon, L.,Haslam, C.,Hayhow, T.G.,Humphreys, P.G.,Joberty, G.,Katso, R.,Kruidenier, L.,Leveridge, M.,Liddle, J.,Mosley, J.,Muelbaier, M.,Randle, R.,Rioja, I.,Rueger, A.,Seal, G.A.,Sheppard, R.J.,Singh, O.,Taylor, J.,Thomas, P.,Thomson, D.,Wilson, D.M.,Lee, K.,Prinjha, R.K.; Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives.; J.Med.Chem., 59:1357-, 2016; PubMed: 26771107; DOI: 10.1021/ACS.JMEDCHEM.5B01537

実験手法

X-RAY DIFFRACTION (1.91 Å)