5FON

Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain (apo structure)

5FON の概要

• エントリーDOI: 10.2210/pdb5fon/pdb
• 関連するPDBエントリー: 5FO4 5FOC 5FOD 5FOF 5FOG 5FOL 5FOM
• 分子名称: LEUCYL-TRNA SYNTHETASE (3 entities in total)
• 機能のキーワード: ligase, cryptosporidium, leucine-trna ligase (leurs) activity, atp + l-leucine + trna(leucine) give amp + diphosphate + l-leucyl-trna(leucine), post-transfer editing activity of leurs, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of the editing site of leurs
• 由来する生物種: CRYPTOSPORIDIUM MURIS; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 131678.93

構造登録者

Palencia, A.,Liu, R.J.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.D.,Alley, M.R.K.,Rosenthal, P.J.,Hakimi, M.A.,Cusack, S. (登録日: 2015-11-24, 公開日: 2016-08-03, 最終更新日: 2024-01-10)

• 主引用文献: Palencia, A.,Liu, R.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.,Li, X.,Alley, M.R.K.,Freund, Y.R.,Rosenthal, P.J.,Hakimi, M.,Cusack, S.; Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.; Antimicrob.Agents Chemother., 60:5817-, 2016; PubMed: 27431220; DOI: 10.1128/AAC.00873-16

実験手法

X-RAY DIFFRACTION (2.7 Å)