5EGR

tRNA guanine transglycosylase (TGT) in complex with an Immucillin derivative

Summary for 5EGR

• Entry DOI: 10.2210/pdb5egr/pdb
• Related: 1P0D 1PUD 4KWO 4LBU 4LEQ
• Descriptor: Queuine tRNA-ribosyltransferase, GLYCEROL, ZINC ION, ... (6 entities in total)
• Functional Keywords: transition state analog, shigellosis, immucillin, modeling, transferase, transferase inhibitor
• Biological source: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
• Total number of polymer chains: 1
• Total formula weight: 43686.82

Authors

Ehrmann, F.R.,Heine, A.,Klebe, G. (deposition date: 2015-10-27, release date: 2016-11-09, Last modification date: 2024-01-10)

• Primary citation: Ehrmann, F.R.,Hohn, C.,Haertsch, A.,Trapp, N.,Heine, A.,Klebe, G.,Diederich, F.; Synthesis of an Immucillin Derivative as a Class of tRNA-Guanine Transglycosylase Inhibitors: Exploration of a Transition State Analogous Binding Mode; To be Published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)