Crystal structure of Mycobacterium tuberculosis dUTPase R140K, H145W mutant

Summary for 5EDD

Related4GCY 3LOJ 3H6D 3HZA 3I93 2PY4
DescriptorDeoxyuridine 5'-triphosphate nucleotidohydrolase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordsjelly-roll, enzyme-ligand complex, hydrolase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total molecular weight18625.97
Nagy, G.N.,Leveles, I.,Lopata, A.,Harmat, V.,Toth, J.,Vertessy, G.B. (deposition date: 2015-10-21, release date: 2016-11-02, Last modification date: 2016-12-21)
Primary citation
Nagy, G.N.,Suardiaz, R.,Lopata, A.,Ozohanics, O.,Vekey, K.,Brooks, B.R.,Leveles, I.,Toth, J.,Vertessy, B.G.,Rosta, E.
Structural Characterization of Arginine Fingers: Identification of an Arginine Finger for the Pyrophosphatase dUTPases.
J. Am. Chem. Soc., 138:15035-15045, 2016
PubMed: 27740761 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.6b09012
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.217001.9%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution