5EDD

Crystal structure of Mycobacterium tuberculosis dUTPase R140K, H145W mutant

Summary for 5EDD

Entry DOI	10.2210/pdb5edd/pdb
Related	2PY4 3H6D 3HZA 3I93 3LOJ 4GCY
Descriptor	Deoxyuridine 5'-triphosphate nucleotidohydrolase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	jelly-roll, enzyme-ligand complex, hydrolase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	18625.97
Authors	Nagy, G.N.,Leveles, I.,Lopata, A.,Harmat, V.,Toth, J.,Vertessy, G.B. (deposition date: 2015-10-21, release date: 2016-11-02, Last modification date: 2024-01-10)
Primary citation	Nagy, G.N.,Suardiaz, R.,Lopata, A.,Ozohanics, O.,Vekey, K.,Brooks, B.R.,Leveles, I.,Toth, J.,Vertessy, B.G.,Rosta, E. Structural Characterization of Arginine Fingers: Identification of an Arginine Finger for the Pyrophosphatase dUTPases. J. Am. Chem. Soc., 138:15035-15045, 2016 Cited by PubMed: 27740761 DOI: 10.1021/jacs.6b09012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation