3LOJ

Structure of Mycobacterium tuberculosis dUTPase H145A mutant

Summary for 3LOJ

Related3HZA
DescriptorDeoxyuridine 5'-triphosphate nucleotidohydrolase, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, GLYCEROL, ... (7 entities in total)
Functional Keywordshydrolase, jelly roll, domain swapping, nucleotide metabolism, magnesium, metal-binding
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total molecular weight18777.98
Authors
Leveles, I.,Harmat, V.,Pecsi, I.,Lopata, A.,Vertessy, B.G.,Toth, J. (deposition date: 2010-02-04, release date: 2010-08-11, Last modification date: 2017-11-01)
Primary citation
Pecsi, I.,Leveles, I.,Harmat, V.,Vertessy, B.G.,Toth, J.
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
Nucleic Acids Res., 38:7179-7186, 2010
PubMed: 20601405 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkq584
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.183602.6%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution