Crystal structure of dUTPase H145W mutant

Summary for 3HZA

DescriptorDeoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywordsjelly roll, domain swapping, hydrolase, nucleotide metabolism
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total molecular weight18838.17
Leveles, I.,Harmat, V.,Pecsi, I.,Toth, J.,Vertessy, B.G. (deposition date: 2009-06-23, release date: 2009-11-24, Last modification date: 2017-11-01)
Primary citation
Pecsi, I.,Leveles, I.,Harmat, V.,Vertessy, B.G.,Toth, J.
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase.
Nucleic Acids Res., 38:7179-7186, 2010
PubMed: 20601405 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkq584
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers501.7%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution