3HZA

Crystal structure of dUTPase H145W mutant

Summary for 3HZA

DescriptorDeoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywordsjelly roll, domain swapping, hydrolase, nucleotide metabolism
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total molecular weight18838.17
Authors
Leveles, I.,Harmat, V.,Pecsi, I.,Toth, J.,Vertessy, B.G. (deposition date: 2009-06-23, release date: 2009-11-24, Last modification date: 2017-11-01)
Primary citation
Pecsi, I.,Leveles, I.,Harmat, V.,Vertessy, B.G.,Toth, J.
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase.
Nucleic Acids Res., 38:7179-7186, 2010
PubMed: 20601405 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkq584
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers501.7%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution