3HZA

Crystal structure of dUTPase H145W mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004170	molecular_function	dUTP diphosphatase activity
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006226	biological_process	dUMP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046080	biological_process	dUTP metabolic process
A	0046081	biological_process	dUTP catabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 200

Chain	Residue
A	DUP201
A	HOH313
A	HOH316
A	HOH317

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site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE DUP A 201

Chain	Residue
A	THR81
A	ILE82
A	ASP83
A	TYR86
A	ILE90
A	LYS91
A	GLN113
A	ARG140
A	GLY144
A	TRP145
A	GLY146
A	SER147
A	SER148
A	MG200
A	HOH302
A	HOH303
A	HOH305
A	HOH313
A	HOH316
A	HOH317
A	HOH324
A	ARG64
A	SER65
A	GLY66
A	ASN77
A	GLY80

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 202

Chain	Residue
A	ALA6
A	ALA100
A	ALA101
A	PRO102
A	ALA133
A	LEU135
A	HOH386

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 203

Chain	Residue
A	ASP131
A	HOH347
A	HOH442

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TRS A 204

Chain	Residue
A	SER74
A	SER74
A	ILE75
A	VAL76
A	HOH402
A	HOH402
A	HOH402

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00116, ECO:0000269|PubMed:15276840

Chain	Residue	Details
A	ASN77
A	THR81
A	ARG64

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15276840

Chain	Residue	Details
A	LYS91

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