5E8D
Crystal structure of human epiregulin in complex with the Fab fragment of murine monoclonal antibody 9E5
Summary for 5E8D
Entry DOI | 10.2210/pdb5e8d/pdb |
Related | 5AZ2 |
Descriptor | Proepiregulin, anti-human epiregulin antibody 9E5 Fab heavy chain, anti-human epiregulin antibody 9E5 Fab light chain, ... (6 entities in total) |
Functional Keywords | antibody, immunoglobulin, monoclonal antibody, epidermal growth factor, cancer, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 55608.48 |
Authors | Kado, Y.,Mizohata, E.,Nagatoishi, S.,Iijima, M.,Shinoda, K.,Miyafusa, T.,Nakayama, T.,Yoshizumi, T.,Sugiyama, A.,Kawamura, T.,Lee, Y.H.,Matsumura, H.,Doi, H.,Fujitani, H.,Kodama, T.,Shibasaki, Y.,Tsumoto, K.,Inoue, T. (deposition date: 2015-10-14, release date: 2015-12-09, Last modification date: 2020-02-19) |
Primary citation | Kado, Y.,Mizohata, E.,Nagatoishi, S.,Iijima, M.,Shinoda, K.,Miyafusa, T.,Nakayama, T.,Yoshizumi, T.,Sugiyama, A.,Kawamura, T.,Lee, Y.H.,Matsumura, H.,Doi, H.,Fujitani, H.,Kodama, T.,Shibasaki, Y.,Tsumoto, K.,Inoue, T. Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES J.Biol.Chem., 291:2319-2330, 2016 Cited by PubMed: 26627827DOI: 10.1074/jbc.M115.656009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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