5E8D

Crystal structure of human epiregulin in complex with the Fab fragment of murine monoclonal antibody 9E5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005154	molecular_function	epidermal growth factor receptor binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CL H 301

Chain	Residue
H	LEU175

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site_id	AC2
Number of Residues	3
Details	binding site for residue GOL H 302

Chain	Residue
H	PRO124
H	VAL126
H	LYS213

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site_id	AC3
Number of Residues	9
Details	binding site for residue GOL L 301

Chain	Residue
L	LEU159
L	SER175
L	SER176
L	THR177
H	PHE171
H	PRO172
H	THR181
H	LEU182
H	SER183

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Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CrCevGytGVrC

Chain	Residue	Details
A	CYS30-CYS41

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR191-HIS197

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CrCevGYtgvr....C

Chain	Residue	Details
A	CYS30-CYS41

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN-15

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