5E8D

Crystal structure of human epiregulin in complex with the Fab fragment of murine monoclonal antibody 9E5

Summary for 5E8D

• Entry DOI: 10.2210/pdb5e8d/pdb
• Related: 5AZ2
• Descriptor: Proepiregulin, anti-human epiregulin antibody 9E5 Fab heavy chain, anti-human epiregulin antibody 9E5 Fab light chain, ... (6 entities in total)
• Functional Keywords: antibody, immunoglobulin, monoclonal antibody, epidermal growth factor, cancer, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 55608.48

Authors

Kado, Y.,Mizohata, E.,Nagatoishi, S.,Iijima, M.,Shinoda, K.,Miyafusa, T.,Nakayama, T.,Yoshizumi, T.,Sugiyama, A.,Kawamura, T.,Lee, Y.H.,Matsumura, H.,Doi, H.,Fujitani, H.,Kodama, T.,Shibasaki, Y.,Tsumoto, K.,Inoue, T. (deposition date: 2015-10-14, release date: 2015-12-09, Last modification date: 2020-02-19)

• Primary citation: Kado, Y.,Mizohata, E.,Nagatoishi, S.,Iijima, M.,Shinoda, K.,Miyafusa, T.,Nakayama, T.,Yoshizumi, T.,Sugiyama, A.,Kawamura, T.,Lee, Y.H.,Matsumura, H.,Doi, H.,Fujitani, H.,Kodama, T.,Shibasaki, Y.,Tsumoto, K.,Inoue, T.; Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES; J.Biol.Chem., 291:2319-2330, 2016; PubMed: 26627827; DOI: 10.1074/jbc.M115.656009

Experimental method

X-RAY DIFFRACTION (2.5 Å)