5AZ2
Crystal structure of the Fab fragment of 9E5, a murine monoclonal antibody specific for human epiregulin
Summary for 5AZ2
| Entry DOI | 10.2210/pdb5az2/pdb |
| Descriptor | anti-human epiregulin antibody 9E5 Fab heavy chain, anti-human epiregulin antibody 9E5 Fab light chain (3 entities in total) |
| Functional Keywords | antibody, immunoglobulin, monoclonal antibody, epidermal growth factor, immune system |
| Biological source | Mus musculus More |
| Total number of polymer chains | 2 |
| Total formula weight | 47294.72 |
| Authors | Kado, Y.,Mizohata, E.,Nagatoishi, S.,Iijima, M.,Shinoda, K.,Miyafusa, T.,Nakayama, T.,Yoshizumi, T.,Sugiyama, A.,Kawamura, T.,Lee, Y.H.,Matsumura, H.,Doi, H.,Fujitani, H.,Kodama, T.,Shibasaki, Y.,Tsumoto, K.,Inoue, T. (deposition date: 2015-09-16, release date: 2015-12-09, Last modification date: 2020-02-26) |
| Primary citation | Kado, Y.,Mizohata, E.,Nagatoishi, S.,Iijima, M.,Shinoda, K.,Miyafusa, T.,Nakayama, T.,Yoshizumi, T.,Sugiyama, A.,Kawamura, T.,Lee, Y.H.,Matsumura, H.,Doi, H.,Fujitani, H.,Kodama, T.,Shibasaki, Y.,Tsumoto, K.,Inoue, T. Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES J.Biol.Chem., 291:2319-2330, 2016 Cited by PubMed: 26627827DOI: 10.1074/jbc.M115.656009 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.603 Å) |
Structure validation
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