5E0U

Human PCNA variant (S228I) complexed with p21 at 1.9 Angstroms

Summary for 5E0U

Entry DOI	10.2210/pdb5e0u/pdb
Related	1AXC 5E0T 5E0V
Descriptor	Proliferating cell nuclear antigen, Cyclin-dependent kinase inhibitor 1 (3 entities in total)
Functional Keywords	dna replication, sliding clamp, dna binding protein
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : P12004 Cytoplasm: P38936
Total number of polymer chains	6
Total formula weight	95112.62
Authors	Duffy, C.M.,Hilbert, B.J.,Kelch, B.A. (deposition date: 2015-09-29, release date: 2016-04-20, Last modification date: 2023-09-27)
Primary citation	Duffy, C.M.,Hilbert, B.J.,Kelch, B.A. A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. J.Mol.Biol., 428:1023-1040, 2016 Cited by PubMed: 26688547 DOI: 10.1016/j.jmb.2015.11.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation